徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
PGP Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2610936 |
| 100ul | WGD-Z-2610936 |
详细参数
| 别名 | Glycerol-3-phosphate phosphatase; G3PP; Aspartate-based ubiquitous Mg(2+)-dependent phosphatase; AUM; Phosphoglycolate phosphatase; PGP |
| 基因名 | PGP |
| UniProt ID | A6NDG6 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9M7-P7-A9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 34 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Phosphoglycolate phosphatase (PGP) is a conserved cytosolic hydrolase of the haloacid dehalogenase family that functions as a metabolic proofreading enzyme. It specifically dephosphorylates 2-phosphoglycolate and related damage metabolites, such as 2-phospho-L-lactate, which are generated during oxidative DNA damage repair. By clearing these metabolites, PGP prevents the inhibition of key glycolytic enzymes, including triosephosphate isomerase and phosphofructokinase, thereby maintaining metabolic flux. PGP activity is essential for embryonic development and sustained cell proliferation, as it couples the products of DNA repair to intermediary metabolism. Its critical role in cellular survival is further evidenced by its necessity for parasite viability in Plasmodium species, suggesting its importance across diverse biological systems. |