徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
TNFRSF10C Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2610970 |
| 100ul | WGD-Z-2610970 |
详细参数
| 别名 | Tumor necrosis factor receptor superfamily member 10C; Antagonist decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor without death domain; Decoy receptor 1; DcR1; Lymphocyte inhibitor of TRAIL; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; TRAIL receptor without an intracellular domain; CD antigen CD263 |
| 基因名 | DcR1/CD263 |
| UniProt ID | O14798 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 3S8-N6-G5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 27 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | TNF receptor superfamily member 10c (DcR1/CD263) is a cell surface protein that functions as a decoy receptor within the tumor necrosis factor (TNF) signaling pathway. While it possesses an extracellular TRAIL-binding domain similar to death receptors, it lacks a functional intracellular death domain and is anchored to the membrane via a GPI linkage. Consequently, it is incapable of initiating apoptotic signaling. Instead, it acts as an antagonist by competing with pro-apoptotic receptors, such as DR4 and DR5, for binding to the ligand TRAIL, thereby protecting cells from TRAIL-mediated cell death. The expression of this receptor is regulated by p53 and is inducible by DNA damage. Notably, while widely expressed in normal tissues, it is frequently downregulated or absent in many cancer cell lines, contributing to the selective sensitivity of malignant cells to TRAIL-induced apoptosis. |