徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
DNPH1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611009 |
| 100ul | WGD-Z-2611009 |
详细参数
| 别名 | 5-hydroxymethyl-dUMP N-hydrolase; 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; c-Myc-responsive protein RCL |
| 基因名 | DNPH1 |
| UniProt ID | O43598 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7V9-M2-T4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 19 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (DNPH1) is an enzyme that catalyzes the hydrolysis of glycosidic bonds in deoxyribonucleotides, specifically detoxifying 5-hydroxymethyl-dUMP (hmdUMP) to prevent its misincorporation into DNA. By modulating the nucleotide pool, DNPH1 protects genomic integrity and contributes to cell proliferation regulation. Upregulated by c-Myc, it supports the metabolic demands of rapidly dividing cells. Inhibition of DNPH1 sensitizes cancer cells to PARP inhibitors and chemotherapy by accumulating cytotoxic nucleotides. |