徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
GMNN Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611057 |
| 100ul | WGD-Z-2611057 |
详细参数
| 别名 | Geminin |
| 基因名 | GMNN |
| UniProt ID | O75496 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5X7-B6-Y1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 23 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Geminin DNA replication inhibitor (GMNN) is a nuclear protein that strictly regulates DNA replication and cell cycle progression. It functions by binding to the replication factor Cdt1, preventing the re-loading of the MCM complex onto chromatin and ensuring that DNA replication occurs only once per cell cycle. Geminin levels fluctuate during the cell cycle, accumulating in S and G2 phases and being degraded during mitosis. Beyond replication control, Geminin influences cell lineage commitment and neural differentiation through interactions with chromatin remodeling complexes. Its overexpression is linked to various cancers, acting as an oncogenic factor, while germline mutations are associated with Meier-Gorlin syndrome, highlighting its role in development and genomic stability. |