徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
EED Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611060 |
| 100ul | WGD-Z-2611060 |
详细参数
| 别名 | Polycomb protein EED; hEED; Embryonic ectoderm development protein; WD protein associating with integrin cytoplasmic tails 1; WAIT-1 |
| 基因名 | EED |
| UniProt ID | O75530 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 7P6-H6-M2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 50 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Embryonic ectoderm development (EED) is a core scaffold subunit of the Polycomb repressive complex 2 (PRC2), which is essential for the epigenetic maintenance of transcriptionally silent chromatin. EED contains a C-terminal WD40 beta-propeller domain that specifically recognizes and binds to trimethylated histone H3 lysine 27 (H3K27me3). This binding event allosterically stimulates the methyltransferase activity of the PRC2 complex, thereby facilitating the propagation of repressive histone marks across cell divisions. Through this mechanism, EED plays an indispensable role in regulating stem cell pluripotency, self-renewal, and lineage commitment during embryonic development. Pathogenic variants in the EED gene are established causes of overgrowth and neurodevelopmental disorders, including phenotypes that closely resemble Weaver syndrome. Furthermore, dysregulation of the EED-PRC2 axis is frequently implicated in various forms of cancer. |