徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CCN4 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611085 |
| 100ul | WGD-Z-2611085 |
详细参数
| 别名 | CCN family member 4; WNT1-inducible-signaling pathway protein 1; WISP-1; Wnt-1-induced secreted protein |
| 基因名 | CCN4 |
| UniProt ID | O95388 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9B4-W7-K3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 40 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Cellular communication network factor 4 (CCN4) is a secreted matricellular protein of the CCN/CTGF family that functions as a downstream regulator of the Wnt/Frizzled signaling pathway. It contains conserved modular domains that enable interactions with the extracellular matrix, integrins, and various growth factors to modulate cell adhesion, migration, proliferation, and differentiation. CCN4 plays a significant role in promoting cell survival and attenuating p53-mediated apoptosis following DNA damage. In pathological contexts, CCN4 is frequently upregulated in various malignancies, particularly melanoma, where it drives epithelial-mesenchymal transition, glycolysis, and metastasis. Furthermore, it contributes to tumor-induced immunosuppression by recruiting myeloid-derived suppressor cells and inhibiting the activity of CD8+ T and NK cells. These roles establish CCN4 as a key factor in tumor progression and an emerging target for therapeutic intervention. |