徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CA1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611109 |
| 100ul | WGD-Z-2611109 |
详细参数
| 别名 | Carbonic anhydrase 1; Carbonate dehydratase I; Carbonic anhydrase B; CAB; Carbonic anhydrase I; CA-I; Cyanamide hydratase CA1 |
| 基因名 | Carbonic Anhydrase 1 |
| UniProt ID | P00915 |
| 反应种属 | Human,Rat |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 1L1-O2-N5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 28 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Carbonic anhydrase 1 (CA1) is a cytosolic zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide to bicarbonate and protons. It is abundant in erythrocytes, the gastrointestinal tract, and cardiac tissue, contributing to pH homeostasis and ion transport. Although catalytically less efficient than the ubiquitous CA2, CA1 plays significant roles in specific pathological contexts. Elevated CA1 levels in diabetic cardiomyopathy promote endothelial cell apoptosis and tissue remodeling. Additionally, CA1-mediated pathways are implicated in vascular permeability and retinal edema in diabetic retinopathy. Its inhibition is explored as a therapeutic strategy for these vascular and metabolic complications. |