徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
ENG Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611250 |
| 100ul | WGD-Z-2611250 |
详细参数
| 别名 | Endoglin; CD antigen CD105 |
| 基因名 | CD105 |
| UniProt ID | P17813 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 9V9-G4-M4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 70 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Endoglin (ENG), also known as CD105, is a type I membrane glycoprotein primarily associated with human vascular endothelium. It is part of the TGF-beta receptor complex and plays a crucial role in angiogenesis, which is essential for tumor growth, survival, and metastasis of cancer cells. Structurally, endoglin consists of a homodimer of 180 kDA stabilized by intermolecular disulfide bonds, with a large extracellular domain, a hydrophobic transmembrane domain, and a short cytoplasmic tail. Functionally, it acts as an auxiliary receptor for the TGF-beta receptor complex, modulating responses to TGF-beta1, TGF-beta3, activin-A, BMP-2, BMP-7, and BMP-9, and is involved in cytoskeletal organization, affecting cell morphology and migration. Mutations in the ENG gene are associated with hereditary hemorrhagic telangiectasia type 1 (HHT1), a disorder characterized by vascular malformations and bleeding. The protein's expression is regulated during heart development, and experimental mice lacking the endoglin gene die due to cardiovascular abnormalities. |