徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
IL11 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611270 |
| 100ul | WGD-Z-2611270 |
详细参数
| 别名 | Interleukin-11; IL-11; Adipogenesis inhibitory factor; AGIF; Oprelvekin |
| 基因名 | IL11 |
| UniProt ID | P20809 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6X2-S4-Q6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 21 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Interleukin 11 (IL-11) is a cytokine that was initially thought to be important for hematopoiesis and platelet production, but more recent studies have revealed a more complex role for IL-11 in disease pathobiology. While IL-11 was previously considered to have anti-inflammatory and regenerative effects, newer research has shown that IL-11 is actually pro-fibrotic, pro-inflammatory, and anti-regenerative . IL-11 signaling pathways converge to cause mesenchymal transitions and a pro-inflammatory state across different cell types, leading to stromal inflammation, fibrosis, loss of specialized cellular functions, and organ failure . IL-11 is upregulated in response to various disease factors as an "alarmin-like" response, and its overexpression has been associated with a number of diseases, including certain cancers, fibrotic diseases, and vascular diseases . As a result, IL-11 is now viewed as a potential therapeutic target, with several clinical trials investigating anti-IL-11 therapies for fibrotic diseases . |