徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CD9 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611275 |
| 100ul | WGD-Z-2611275 |
详细参数
| 别名 | CD9 antigen; 5H9 antigen; Cell growth-inhibiting gene 2 protein; Leukocyte antigen MIC3; Motility-related protein; MRP-1; Tetraspanin-29; Tspan-29; p24; CD antigen CD9 |
| 基因名 | CD9 |
| UniProt ID | P21926 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 9Z1-A9-K8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 25 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | CD9 is a tetraspanin membrane protein (also called Tspan29) with four transmembrane helices and two extracellular loops, forming part of tetraspanin-enriched microdomains that organize partner proteins such as integrins, immunoglobulin superfamily members, and metalloproteases at the plasma membrane. It regulates cell adhesion, migration, membrane curvature, and signal transduction in many cell types, including leukocytes, endothelial cells, oocytes, and cancer cells, partly by clustering adhesion receptors (for example ICAM‑1, VCAM‑1, ALCAM) and modulating ADAM17 sheddase activity. Functionally, CD9 is crucial for sperm–egg membrane fusion and female fertility, and it also influences exosome biogenesis and uptake. Clinically, altered CD9 expression is linked to cancer progression and prognosis in several tumors, where it can either promote dissemination or restrain invasion depending on context, and it serves as a diagnostic and prognostic marker in acute leukemias and a potential therapeutic target. |