徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
PAICS Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611276 |
| 100ul | WGD-Z-2611276 |
详细参数
| 别名 | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase; AIR carboxylase; AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase; SAICAR synthetase] |
| 基因名 | PAICS |
| UniProt ID | P22234 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7X6-J2-U7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 47 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS) is a bifunctional cytosolic enzyme essential for the de novo purine biosynthetic pathway. It catalyzes the sequential conversion of aminoimidazole ribotide (AIR) to carboxyaminoimidazole ribotide (CAIR) and subsequently to succinylaminoimidazolecarboxamide ribotide (SAICAR). Structurally, PAICS forms a homo-octamer that enables efficient substrate channeling between its carboxylase and synthetase domains. The enzyme is a key component of the purinosome, a multienzyme complex that assembles to meet high cellular demands for purines. Clinically, PAICS is overexpressed in numerous malignancies, including lung adenocarcinoma and prostate cancer, where it promotes metabolic reprogramming, cell proliferation, and epithelial-mesenchymal transition. |