徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
PSMB6 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611308 |
| 100ul | WGD-Z-2611308 |
详细参数
| 别名 | Proteasome subunit beta type-6; Macropain delta chain; Multicatalytic endopeptidase complex delta chain; Proteasome delta chain; Proteasome subunit Y; Proteasome subunit beta-1; beta-1 |
| 基因名 | PSMB6 |
| UniProt ID | P28072 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 8W5-T7-M5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 25 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Proteasome 20S subunit beta 6 (PSMB6) is a crucial component of the 20S core proteasome complex, which is responsible for the proteolytic degradation of most intracellular proteins. This 22 kDa protein, encoded by the PSMB6 gene on chromosome 17p13.2, is part of the proteasome B-type family and exhibits caspase-like activity, cleaving after acidic residues. PSMB6 contributes to the assembly of the proteolytic chamber within the 20S proteasome, playing a vital role in protein quality control and regulation of various cellular processes. In the immune system, PSMB6 can be replaced by the inducible subunit PSMB9 to form the immunoproteasome, enhancing antigen processing. Dysregulation of PSMB6 has been implicated in various diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer, making it a potential target for therapeutic interventions. |