徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
NOS3 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611319 |
| 100ul | WGD-Z-2611319 |
详细参数
| 别名 | Nitric oxide synthase 3; Constitutive NOS; cNOS; EC-NOS; NOS type III; NOSIII; Nitric oxide synthase; endothelial; Endothelial NOS; eNOS |
| 基因名 | NOS3 |
| UniProt ID | P29474 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9F5-X8-H9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 133 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Nitric oxide synthase 3 (NOS3), also known as endothelial nitric oxide synthase (eNOS), is an enzyme that catalyzes the production of nitric oxide (NO) from L-arginine in endothelial cells. This protein plays a crucial role in regulating vascular tone, promoting vasodilation, and maintaining blood flow through a cyclic guanosine monophosphate (cGMP)-mediated signaling pathway. NOS3 is a dimeric enzyme composed of two identical subunits, each containing a reductase domain and an oxidase domain, which require calcium and calmodulin for activation. Dysregulation of NOS3 is associated with several cardiovascular diseases, including hypertension, atherosclerosis, and coronary artery disease, where impaired NO production can lead to endothelial dysfunction and increased vascular resistance. Genetic variations in the NOS3 gene have also been linked to susceptibility to conditions such as stroke and ischemic heart disease. |