徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
NOS1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611320 |
| 100ul | WGD-Z-2611320 |
详细参数
| 别名 | Nitric oxide synthase 1; Constitutive NOS; NC-NOS; NOS type I; Neuronal NOS; N-NOS; nNOS; Nitric oxide synthase; brain; bNOS; Peptidyl-cysteine S-nitrosylase NOS1 |
| 基因名 | NOS1 |
| UniProt ID | P29475 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6G3-K2-B9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 160 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Nitric oxide synthase 1 (NOS1) is a homodimeric enzyme responsible for the production of nitric oxide (NO) from L-arginine. It utilizes several cofactors, including NADPH, FAD, FMN, heme, and tetrahydrobiopterin, and is activated by calcium-dependent calmodulin binding. Predominantly expressed in neurons, NOS1 regulates neurotransmission, synaptic plasticity, and neurodevelopment through its interaction with PSD-95 via PDZ motifs. It also plays essential roles in skeletal muscle contractility and the regulation of vascular tone. Clinically, dysregulation of NOS1 is associated with neurotoxicity in stroke and neurodegenerative diseases due to excessive NO production and subsequent S-nitrosylation. Furthermore, NOS1 uncoupling under oxidative stress can lead to the generation of reactive oxygen species, contributing to heart failure and atherogenesis. |