徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CD6 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611327 |
| 100ul | WGD-Z-2611327 |
详细参数
| 别名 | T-cell differentiation antigen CD6; T12; TP120; CD antigen CD6) [Cleaved into: Soluble CD6] |
| 基因名 | CD6 |
| UniProt ID | P30203 |
| 反应种属 | Human |
| 应用 | IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7S6-T1-T7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 71 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200; ELISA-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | T-cell differentiation antigen CD6 (CD6) is a type I transmembrane glycoprotein primarily expressed on T lymphocytes, playing a crucial role in immune responses. CD6 interacts with its ligand, CD166, enhancing T-cell activation and promoting cell survival. This interaction is essential for the formation of a signaling complex that modulates T-cell responses, making CD6 a potential co-stimulatory receptor. However, its role can be context-dependent, exhibiting both co-stimulatory and inhibitory functions based on the cellular environment and the specific immune context. Dysregulation of CD6 has been implicated in various autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it may contribute to the pathogenesis by affecting T-cell activation and differentiation. In these conditions, altered CD6 expression can lead to excessive T-cell activation, promoting inflammation and tissue damage. |