徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CHI3L1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611354 |
| 100ul | WGD-Z-2611354 |
详细参数
| 别名 | Chitinase-3-like protein 1; 39 kDa synovial protein; Cartilage glycoprotein 39; CGP-39; GP-39; hCGP-39; YKL-40 |
| 基因名 | CHI3L1 |
| UniProt ID | P36222 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 5U6-J2-D8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 42 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Chitinase 3 like 1 (CHI3L1) is a secreted glycoprotein and member of the glycosyl hydrolase 18 family that functions as a carbohydrate-binding lectin. Although it lacks chitinase enzymatic activity, it retains a high-affinity carbohydrate-binding motif for chitin and chito-oligosaccharides. CHI3L1 is produced by various cell types, including activated macrophages, neutrophils, and endothelial cells, and is involved in tissue remodeling and cell survival. It plays a significant role in activating Akt signaling pathways and stimulating IL-8 production, which are key drivers of chronic inflammation. Clinically, CHI3L1 is a prominent biomarker for multiple pathological conditions, including fibrosis and various cancers. It is particularly associated with colitis-related neoplastic changes and atherogenesis, making it a valuable target for therapeutic intervention in inflammatory and malignant diseases. |