徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
GDNF Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611361 |
| 100ul | WGD-Z-2611361 |
详细参数
| 别名 | Glial cell line-derived neurotrophic factor; hGDNF; Astrocyte-derived trophic factor; ATF |
| 基因名 | GDNF |
| UniProt ID | P39905 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 5F3-N8-O7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 23 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor that plays a critical role in the survival, development, and maintenance of neurons, particularly midbrain dopaminergic neurons. GDNF is initially synthesized as a precursor protein and undergoes proteolytic processing to form its active homodimeric structure, which consists of two 15 kDa monomers linked by disulfide bonds. It signals through the receptor tyrosine kinase RET, with the assistance of glycosylphosphatidylinositol-anchored co-receptors (GFRα1), leading to activation of intracellular pathways that promote neuronal health and survival. Dysregulation of GDNF has been implicated in several diseases, most notably Parkinson's disease, where reduced GDNF levels contribute to the degeneration of dopaminergic neurons. Additionally, mutations in the GDNF gene have been associated with Hirschsprung disease, a condition characterized by intestinal motility issues. |