徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
IL6ST Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611363 |
| 100ul | WGD-Z-2611363 |
详细参数
| 别名 | Interleukin-6 receptor subunit beta; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD antigen CD130 |
| 基因名 | IL6ST |
| UniProt ID | P40189 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3B2-E3-O9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 103 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Interleukin 6 cytokine family signal transducer (IL6ST), also known as gp130, is the shared signaling subunit for the interleukin-6 (IL-6) family of cytokines. It mediates diverse physiological processes, including immune responses, hematopoiesis, and bone metabolism. The receptor consists of an extracellular region with cytokine-binding domains and a cytoplasmic tail that, while lacking intrinsic kinase activity, associates with JAK/STAT, Ras/Raf, and Src-family kinases upon ligand-induced homodimerization. Signaling is initiated when IL-6 binds to IL-6Rα, followed by the recruitment of gp130 to form a high-affinity hexameric complex. Clinically, dysregulation of the IL-6/IL6ST axis is central to the pathogenesis of rheumatoid arthritis, Castleman disease, and cytokine release syndrome. Therapeutic inhibitors targeting this axis are widely used to manage these inflammatory conditions. |