徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CEACAM3 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611365 |
| 100ul | WGD-Z-2611365 |
详细参数
| 别名 | Cell adhesion molecule CEACAM3; Carcinoembryonic antigen CGM1; Carcinoembryonic antigen-related cell adhesion molecule 3; CEA cell adhesion molecule 3; CD antigen CD66d |
| 基因名 | CEACAM3 |
| UniProt ID | P40198 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9U1-V2-S5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 27 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:500-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | CEA cell adhesion molecule 3 (CEACAM3) is a cell adhesion molecule exclusively expressed on human granulocytes that functions as a major receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms. The protein contains a single extracellular IgV-like domain and a distinctive 71-amino-acid cytoplasmic domain featuring an immunoreceptor tyrosine-based activation motif (ITAM)-like sequence. Upon bacterial infection, CEACAM3 becomes phosphorylated by Src family protein tyrosine kinases (particularly Hck and Fgr), with the Y230 residue serving as the central hub for interactions with SH2 domain-containing proteins. This phosphorylation triggers actin-cytoskeleton-dependent engulfment of bacteria and stimulates the small GTPase Rac, a critical regulator of actin cytoskeleton dynamics and oxidative burst. CEACAM3 appears to be a specialized member of the CEACAM family that evolved specifically for innate immune control of human-specific bacterial pathogens, with no homologues found in other mammalian species and no identified endogenous ligands. |