徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
IL15 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611367 |
| 100ul | WGD-Z-2611367 |
详细参数
| 别名 | Interleukin-15; IL-15 |
| 基因名 | IL15 |
| UniProt ID | P40933 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 2I2-H9-E1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 18 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Interleukin-15 (IL-15) is a pleiotropic cytokine that plays a crucial role in regulating both innate and adaptive immune responses. It is involved in the development, proliferation, survival, and differentiation of various immune cells, including natural killer (NK) cells, T cells, and B cells. Dysregulation of IL-15 expression has been implicated in several autoimmune and chronic inflammatory disorders, such as rheumatoid arthritis, multiple sclerosis, psoriasis, systemic lupus erythematosus, and inflammatory bowel disease. In these conditions, increased levels of IL-15 and its receptor (IL-15Rα) contribute to the maintenance of self-reactive memory T cells, bystander activation of inflammatory cells, and upregulation of activating receptors on T cells. Conversely, in some infectious diseases, IL-15 production may be compromised, and exogenous administration of IL-15 can potentially enhance immune responses against pathogens. |