徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
MVK Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611504 |
| 100ul | WGD-Z-2611504 |
详细参数
| 别名 | Mevalonate kinase; MK |
| 基因名 | MVK |
| UniProt ID | Q03426 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 9W4-X8-S6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 42 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Mevalonate kinase (MVK) is an essential enzyme in the mevalonate pathway, which is crucial for cholesterol synthesis and the production of isoprenoids. Specifically, MVK catalyzes the conversion of mevalonic acid to 5-phosphomevalonate, marking the second step in this metabolic pathway. The enzyme is ubiquitously expressed, with significant levels found in leukocytes and skin keratinocytes. MVK plays a vital role in various cellular functions, including cell growth, differentiation, and the maintenance of the cytoskeleton. Mutations in the MVK can lead to mevalonate kinase deficiency, resulting in conditions such as hyperimmunoglobulinemia D syndrome (HIDS) and mevalonic aciduria (MVA). These disorders are characterized by recurrent fever episodes, developmental delays, and other systemic symptoms due to impaired enzyme activity and subsequent accumulation of mevalonic acid. |