徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
PTPN11 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611511 |
| 100ul | WGD-Z-2611511 |
详细参数
| 别名 | Tyrosine-protein phosphatase non-receptor type 11; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3 |
| 基因名 | SHP2 |
| UniProt ID | Q06124 |
| 反应种属 | Human,Mouse,Rat |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6K6-X9-C5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 68 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Protein tyrosine phosphatase non-receptor type 11 (SHP2) is a ubiquitously expressed cytosolic non-receptor tyrosine phosphatase that plays a pivotal role in regulating diverse cellular processes, including proliferation, differentiation, and survival. Structurally, it comprises two N-terminal SH2 domains and a central catalytic PTP domain. In its basal state, SHP2 is autoinhibited by the intramolecular binding of the N-SH2 domain to the PTP domain. Activation occurs when phosphotyrosine-containing sequences bind the SH2 domains, inducing a conformational change that exposes the catalytic site. SHP2 acts as a positive regulator of several key signaling pathways, most notably the RAS/MAPK/ERK cascade, and interacts with various partners such as PI3K, JAK2, and GRB2. It also functions as a critical mediator of the PD-1 immune checkpoint pathway, making it a significant target in immunotherapeutic research and cancer biology. |