徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
PSME1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611514 |
| 100ul | WGD-Z-2611514 |
详细参数
| 别名 | Proteasome activator complex subunit 1; 11S regulator complex subunit alpha; REG-alpha; Activator of multicatalytic protease subunit 1; Interferon gamma up-regulated I-5111 protein; IGUP I-5111; Proteasome activator 28 subunit alpha; PA28a; PA28alpha |
| 基因名 | PSME1 |
| UniProt ID | Q06323 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3O4-O7-Z7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 28 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100; ELISA-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Proteasome activator subunit 1 (PSME1, also known as PA28α or REGα) is a 249‑amino‑acid regulatory protein that forms a heterohexameric ring with PA28β to bind the 20S proteasome and generate the 11S proteasome activator complex, especially in immunoproteasomes. Induced by interferon‑γ, PSME1 enhances proteasomal endopeptidase activity and alters the cleavage pattern of substrates, thereby promoting efficient production of antigenic peptides for loading onto MHC class I molecules and supporting antiviral and antitumor immune surveillance. Functionally, it participates in antigen processing, cell‑cycle regulation and stress responses, with gene ontology annotations including endopeptidase activator activity and roles in antigen processing–cross presentation pathways. Clinically, altered PSME1 expression is reported in several cancers, where high levels can correlate with immune infiltration and immunotherapy‑related signatures, and experimental knockdown reduces tumor cell migration or viral replication in specific models, suggesting a context‑dependent role in oncogenesis and viral infection. |