徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
NTRK2 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611618 |
| 100ul | WGD-Z-2611618 |
详细参数
| 别名 | BDNF/NT-3 growth factors receptor; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B |
| 基因名 | TrkB |
| UniProt ID | Q16620 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1O5-U3-V3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 91 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Neurotrophic receptor tyrosine kinase 2 (TrkB) is a transmembrane receptor that serves as the high-affinity receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). Upon ligand binding, TrkB undergoes dimerization and autophosphorylation, activating downstream signaling cascades including the MAPK/ERK, PI3K/AKT, and PLCgamma pathways. These signals are essential for regulating neuronal survival, differentiation, synaptic plasticity, and morphology. Alternative splicing produces multiple isoforms, such as the full-length catalytic receptor and truncated versions like TrkB.T1, which modulate ligand availability and signaling. Dysregulation or oncogenic fusion of the NTRK2 gene is implicated in various malignancies, including neuroblastoma and glioma. Furthermore, altered TrkB signaling is associated with neurological and psychiatric conditions such as depression, epilepsy, and neurodegenerative diseases. |