徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CLEC12A Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611663 |
| 100ul | WGD-Z-2611663 |
详细参数
| 别名 | C-type lectin domain family 12 member A; C-type lectin-like molecule 1; CLL-1; Dendritic cell-associated lectin 2; DCAL-2; Killer cell C-type lectin-like receptor L1; hKLRL1; Myeloid inhibitory C-type lectin-like receptor; MICL; CD antigen CD371 |
| 基因名 | CLEC12A |
| UniProt ID | Q5QGZ9 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7E3-H8-A5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 30 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | C-type lectin domain family 12 member A (CLEC12A), also known as MICL or CLL-1, is a type II transmembrane glycoprotein and an inhibitory member of the C-type lectin-like receptor superfamily. Predominantly expressed on myeloid cells, it functions as a pattern recognition receptor that binds diverse ligands, including monosodium urate (MSU) crystals and mycobacterial mycolic acid. Upon ligand engagement, CLEC12A undergoes Src-dependent phosphorylation of its cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM), recruiting phosphatases SHP-1 and SHP-2 to dampen pro-inflammatory signaling. This mechanism suppresses neutrophil activation and cytokine release while facilitating antigen cross-presentation and antibacterial autophagy. Clinically, the downregulation of CLEC12A exacerbates inflammatory conditions such as gouty arthritis. Additionally, CLEC12A is a well-established cell surface marker for leukemic blasts in acute myeloid leukemia (AML). |