徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
FMN1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611688 |
| 100ul | WGD-Z-2611688 |
详细参数
| 别名 | Formin-1; Limb deformity protein homolog |
| 基因名 | FMN1 |
| UniProt ID | Q68DA7 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6K4-R4-Q1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 157 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Formin 1 (FMN1), is a multidomain protein that plays a crucial role in the regulation of the actin and microtubule cytoskeleton, impacting essential cellular processes such as cell polarity, migration, and cytokinesis. FMN1 contains several conserved domains, including the formin homology domains FH1 and FH2, which are central to its ability to promote actin filament polymerization and interact with actin-binding proteins like profilin. The FH2 domain enables FMN1 to nucleate actin filaments and associate with the barbed end, while additional domains facilitate interactions with signaling molecules and proper subcellular localization. FMN1 is also involved in the formation of adherens junctions and the assembly of linear actin cables, contributing to cell-cell adhesion and tissue integrity. Mutations in FMN1 have been linked to limb deformities in animal models, highlighting its importance in developmental processes and suggesting a role in congenital limb malformations in humans. |