徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
IL31 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611693 |
| 100ul | WGD-Z-2611693 |
详细参数
| 别名 | Interleukin-31; IL-31 |
| 基因名 | IL31 |
| UniProt ID | Q6EBC2 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3H8-J9-K4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 18 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Interleukin 31 (IL31) is a proinflammatory cytokine primarily produced by activated CD4+ T cells, particularly Th2 cells. It belongs to the gp130/IL-6 cytokine family but uniquely does not utilize the gp130 receptor. Instead, IL-31 signals through a heterodimeric receptor complex composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR), activating multiple intracellular pathways, including JAK/STAT, MAPK, and PI3K/AKT. These signaling cascades are involved in various physiological responses, such as immune regulation and inflammation. IL-31 is implicated in several diseases, notably allergic conditions like atopic dermatitis and allergic contact dermatitis, as well as in cardiovascular issues such as Kawasaki disease and dilated cardiomyopathy. |