徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
KSR2 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611722 |
| 100ul | WGD-Z-2611722 |
详细参数
| 别名 | Kinase suppressor of Ras 2; hKSR2 |
| 基因名 | KSR2 |
| UniProt ID | Q6VAB6 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8Z6-O2-F4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 107 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Kinase suppressor of ras 2 (KSR2) is a large cytosolic scaffold protein that organizes the RAF–MEK–ERK MAPK signaling cascade. Although it possesses low intrinsic kinase activity, it acts as a location-regulated allosteric activator by binding BRAF and MEK1 to facilitate their phosphorylation. Predominantly expressed in the brain and metabolically active tissues, KSR2 also interacts with AMP-activated protein kinase (AMPK) to link Ras/MAPK signaling with energy-sensing pathways, thereby regulating feeding behavior, substrate utilization, and adaptive thermogenesis. Loss-of-function variants in KSR2 are strongly associated with severe early-onset obesity, hyperphagia, reduced basal metabolic rate, and marked insulin resistance, establishing it as a critical regulator of systemic energy homeostasis. |