徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
PIK3AP1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611733 |
| 100ul | WGD-Z-2611733 |
详细参数
| 别名 | Phosphoinositide 3-kinase adapter protein 1; B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1 |
| 基因名 | PIK3AP1 |
| UniProt ID | Q6ZUJ8 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6I2-Z1-V8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 90 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Phosphoinositide 3-kinase adapter protein 1 (PIK3AP1) is a crucial adaptor protein that plays an essential role in the signaling pathways of phosphatidylinositol 3-kinase (PI3K), particularly in immune cells. It contains several functional domains that facilitate interactions with various proteins involved in immune responses, including receptors and kinases. PIK3AP1 is involved in regulating cell survival, proliferation, and differentiation, particularly in lymphocytes, where it modulates signaling from the B-cell receptor and other surface receptors. Dysregulation of PIK3AP1 has been linked to various diseases, notably autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, where altered signaling can lead to inappropriate immune activation and inflammation. Additionally, PIK3AP1 has been implicated in cancer biology; its expression levels can influence tumor growth and metastasis by affecting the PI3K/Akt signaling pathway. |