徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
DPPA4 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611737 |
| 100ul | WGD-Z-2611737 |
详细参数
| 别名 | Developmental pluripotency-associated protein 4 |
| 基因名 | DPPA4 |
| UniProt ID | Q7L190 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8R5-Y2-Z9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 33 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Developmental pluripotency associated 4 (DPPA4) is a crucial transcription factor involved in maintaining pluripotency in embryonic stem cells (ESCs). It is highly expressed in ESCs and plays a significant role in self-renewal and pluripotency sustainability. DPPA4 overexpression has been shown to inhibit differentiation and promote proliferation in ESCs by regulating genes involved in the G1/S transition and modulating chromatin structure. In cancer, DPPA4 is re-expressed in several malignant tumors, including colon cancer, and is identified as a new pluripotency-related oncogene. Its upregulation is correlated with poor prognosis and metastasis in colon cancer patients. DPPA4 primarily associates with active chromatin domains and influences chromatin modifications at target genes. |