徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
SETD3 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611752 |
| 100ul | WGD-Z-2611752 |
详细参数
| 别名 | Actin-histidine N-methyltransferase; Protein-L-histidine N-tele-methyltransferase; SET domain-containing protein 3; hSETD3 |
| 基因名 | SETD3 |
| UniProt ID | Q86TU7 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 7F7-V4-Q7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 67 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | SET domain containing 3, actin N3(tau)-histidine methyltransferase (SETD3) is a highly specific S-adenosyl-L-methionine-dependent enzyme that methylates β-actin at the His73 residue. This post-translational modification is critical for promoting F-actin polymerization and maintaining cytoskeletal organization. SETD3 localizes to the cytoplasm and the outer mitochondrial membrane, where it facilitates actin assembly around mitochondria to regulate their morphology, motility, and oxidative phosphorylation. Loss of SETD3 activity results in fragmented mitochondrial networks and a metabolic shift toward glycolysis. Pathophysiologically, SETD3 is required for the efficient replication of enteroviruses and has been implicated in certain hematologic malignancies. Its role in coordinating the cytoskeleton with mitochondrial function suggests it is a key player in cellular mechanotransduction and energy metabolism. |