徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CNTN4 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611786 |
| 100ul | WGD-Z-2611786 |
详细参数
| 别名 | Contactin-4; Brain-derived immunoglobulin superfamily protein 2; BIG-2 |
| 基因名 | BIG-2 |
| UniProt ID | Q8IWV2 |
| 反应种属 | Human,Mouse |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6U9-Q3-G8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 113 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Contactin 4 (BIG-2) is a neuronal cell adhesion molecule of the immunoglobulin superfamily anchored to the plasma membrane via a GPI moiety. It contains six Ig-like and four fibronectin type III domains, which mediate homophilic and heterophilic cell-cell interactions. Contactin 4 is highly expressed in the developing brain, where it promotes neurite outgrowth and participates in axon guidance, fasciculation, and synaptogenesis. It is particularly critical for the precise convergence of olfactory sensory neuron axons onto their target glomeruli. Clinically, Contactin 4 is a dosage-sensitive locus implicated in neurodevelopmental disorders. Heterozygous deletions or disruptive variants in the CNTN4 gene are associated with autism spectrum disorder, intellectual disability, and 3p deletion syndrome. These conditions are often characterized by developmental delay and dysmorphic features, highlighting the protein's essential role in neural circuit formation. |