徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
WWC1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611788 |
| 100ul | WGD-Z-2611788 |
详细参数
| 别名 | Protein KIBRA; HBeAg-binding protein 3; Kidney and brain protein; KIBRA; WW domain-containing protein 1 |
| 基因名 | WWC1 |
| UniProt ID | Q8IX03 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1R6-R6-X2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 125 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | WW and C2 domain containing 1 (WWC1), also known as KIBRA, is a cytoplasmic scaffolding protein that integrates multiple signaling pathways via its WW, C2, and PDZ-binding domains. It acts as a critical regulator of the Hippo signaling pathway by promoting LATS kinase activity and suppressing YAP-dependent transcription, thereby controlling cell proliferation and organ size. In the nervous system, WWC1 modulates synaptic plasticity and AMPA receptor trafficking, processes underlying learning and memory. Genetic variations in WWC1 are associated with human memory performance and cognitive traits. Furthermore, its involvement in dendritic spinogenesis and protein trafficking links it to neurodegenerative conditions, including Alzheimer’s disease. |