徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
MCEMP1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611790 |
| 100ul | WGD-Z-2611790 |
详细参数
| 别名 | Mast cell-expressed membrane protein 1 |
| 基因名 | MCEMP1 |
| UniProt ID | Q8IX19 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5R9-I6-T4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 21 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Mast cell expressed membrane protein 1 (MCEMP1) is a single-pass type II transmembrane protein predominantly expressed in myeloid lineage cells, including lung-resident mast cells, classical monocytes, and alveolar macrophages. It functions as an adaptor for the receptor tyrosine kinase KIT, facilitating stem cell factor (SCF)-mediated mast cell proliferation through its immunoreceptor tyrosine-based activation motif, enhancing KIT autophosphorylation and downstream signaling. MCEMP1 is upregulated by transforming growth factor beta (TGFβ) via SMAD3 and SP1 transcription factors, influencing monocyte chemotaxis, adhesion, and migration by modulating RHO GTPase activity. Its expression is markedly increased in inflammatory lung conditions such as asthma and idiopathic pulmonary fibrosis (IPF), correlating with disease severity. In asthma models, MCEMP1 deficiency reduces airway inflammation and lung impairment, while in IPF, elevated MCEMP1 in monocytes and alveolar macrophages associates with poor prognosis and promotes fibrotic progression by regulating immune cell migration and activation. |