徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
KIRREL3 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611804 |
| 100ul | WGD-Z-2611804 |
详细参数
| 别名 | Kin of IRRE-like protein 3; Kin of irregular chiasm-like protein 3; Nephrin-like protein 2) [Cleaved into: Processed kin of IRRE-like protein 3] |
| 基因名 | KIRREL3 |
| UniProt ID | Q8IZU9 |
| 反应种属 | Human,Rat |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5E8-I5-V6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 85 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Kin of IRRE-like protein 3 (KIRREL3) is a member of the immunoglobulin superfamily, functioning primarily as a cell-adhesion molecule that plays a crucial role in synapse formation and neuronal connectivity during brain development. KIRREL3 is characterized by its single-pass transmembrane structure, containing five extracellular immunoglobulin-like domains and an intracellular PDZ-binding motif, which facilitates homophilic interactions between adjacent neurons. Dysregulation or mutations in the KIRREL3 gene have been linked to several neurodevelopmental disorders, including autism spectrum disorders and intellectual disabilities, where variants can impair synaptic function and connectivity. Research has shown that KIRREL3 is essential for the formation of specific synapses in the hippocampus, particularly those connecting dentate gyrus neurons with GABAergic neurons. |