徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CBLL2 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611818 |
| 100ul | WGD-Z-2611818 |
详细参数
| 别名 | E3 ubiquitin-protein ligase CBLL2; Cbl proto-oncogene-like protein 2; RING-type E3 ubiquitin transferase ZNF645; Zinc finger protein 645; c-Cbl-like protein 2 |
| 基因名 | CBLL2 |
| UniProt ID | Q8N7E2 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 1N9-G1-B2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 48 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Cbl proto-oncogene like 2 (CBLL2), also known as ZNF645, is a zinc finger protein characterized by the presence of both RING-type and C2H2-type zinc finger domains. It functions as an E3 ubiquitin-protein ligase, utilizing a specialized phosphotyrosine-binding domain to target E-cadherin for ubiquitin-mediated degradation. This activity is a critical regulator of cell-cell adhesion and is implicated in the epithelial-mesenchymal transition, a process essential for tissue remodeling and cellular migration. CBLL2 is also expressed during human sperm production, suggesting a role in reproductive biology and quality control. By modulating the stability of adhesion molecules like E-cadherin, CBLL2 serves as a molecular switch that can influence cellular architecture and signaling pathways associated with both normal development and the disruption of epithelial integrity. |