徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
DNER Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611831 |
| 100ul | WGD-Z-2611831 |
详细参数
| 别名 | Delta and Notch-like epidermal growth factor-related receptor |
| 基因名 | DNER |
| UniProt ID | Q8NFT8 |
| 反应种属 | Human,Mouse |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4O2-K1-D4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 78 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000-1:2000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Delta/Notch like EGF Repeat Containing (DNER) is a single-pass type I transmembrane protein characterized by multiple epidermal growth factor (EGF)-like repeats, which mediate cell-cell interactions. Predominantly expressed in the brain, DNER functions as a Notch ligand, regulating neuron-glia communication and neuronal differentiation. It contains 12 EGF-like domains and a Delta/Serrate/LAG-2 (DSL) motif, enabling interactions with Notch receptors to activate downstream signaling pathways critical for cerebellar development and synaptic plasticity. DNER is implicated in astrocyte-mediated regulation of Purkinje cell morphology and function, underscoring its role in central nervous system homeostasis. Dysregulation of DNER is associated with neurological disorders, including autosomal recessive spinocerebellar ataxia type 14 (SCAR14), characterized by cerebellar atrophy, gait abnormalities, and intellectual disability. Additionally, altered DNER expression has been observed in certain cancers, such as breast cancer and glioblastoma, where it may influence tumor progression via Notch-dependent mechanisms. |