徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
SP7 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611842 |
| 100ul | WGD-Z-2611842 |
详细参数
| 别名 | Transcription factor Sp7; Zinc finger protein osterix |
| 基因名 | SP7 |
| UniProt ID | Q8TDD2 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7V7-B1-C5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 44 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Sp7 transcription factor (SP7), also known as Osterix, is a bone-specific zinc-finger transcriptional activator essential for osteoblast differentiation and skeletal formation. It functions downstream of Runx2, binding GC-rich motifs or interacting with Dlx factors to regulate the expression of major bone matrix genes like COL1A1 and BGLAP. SP7 controls the commitment and maturation of the osteoblast lineage, maintaining cortical bone integrity. Pathogenic variants in SP7 cause skeletal dysplasias, including forms of osteogenesis imperfecta characterized by bone fragility. Furthermore, genetic variations in SP7 are associated with bone mineral density variability and osteoporosis susceptibility. |