徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
PHF10 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611851 |
| 100ul | WGD-Z-2611851 |
详细参数
| 别名 | PHD finger protein 10; BRG1-associated factor 45a; BAF45a; XAP135 |
| 基因名 | PHF10 |
| UniProt ID | Q8WUB8 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 3S8-W4-Y8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 56 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | PHD finger protein 10 (PHF10), also known as BAF45A, is a nuclear component of the neural progenitor-specific BAF (npBAF) chromatin-remodeling complex. Containing two PHD zinc-finger domains, it regulates transcription and chromatin structure essential for the proliferation and self-renewal of neural progenitor cells. As neurons differentiate, PHF10 is replaced by homologous subunits in the nBAF complex. It also participates in DNA damage responses and homologous recombination. Clinically, PHF10 dysfunction is associated with intellectual developmental disorders and chromosome 6q deletion syndromes, while its overexpression supports cell proliferation in various cancers. |