徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
TTN Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611865 |
| 100ul | WGD-Z-2611865 |
详细参数
| 别名 | Titin; Connectin; Rhabdomyosarcoma antigen MU-RMS-40.14 |
| 基因名 | TTN |
| UniProt ID | Q8WZ42 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9V2-M2-P8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 3816 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Titin (TTN) is the largest known human protein, functioning as a giant molecular spring and structural scaffold within the sarcomeres of striated muscle. It spans half the length of the sarcomere, from the Z-disc to the M-line, where it interacts with key proteins including telethonin, alpha-actinin, actin, and myosin. Titin is responsible for generating passive tension during muscle stretch and ensuring the precise assembly and alignment of thick filaments. Its extensible I-band region provides elasticity, while its C-terminal kinase domain participates in mechanical strain-dependent signaling. The mechanical properties of titin are further tuned by alternative splicing and post-translational modifications such as phosphorylation. Clinically, truncating variants in the TTN gene are the most common genetic cause of dilated cardiomyopathy (DCM), accounting for approximately 20% of familial cases. |