徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
FAM3C Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611867 |
| 100ul | WGD-Z-2611867 |
详细参数
| 别名 | Protein FAM3C; Interleukin-like EMT inducer |
| 基因名 | FAM3C |
| UniProt ID | Q92520 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 9R4-B5-W8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 24 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | FAM3 metabolism regulating signaling molecule C (FAM3C), also known as interleukin-like EMT inducer (ILEI), is a secreted protein characterized by a GG domain and is part of the FAM3 family, encoded by the FAM3C gene on human chromosome 7. Structurally, FAM3C exists as both monomers and covalent dimers, displaying a unique β-β-α fold rather than the classical four-helix-bundle typical of interleukins, indicating it is not evolutionarily related to interleukins. Functionally, FAM3C is implicated in promoting epithelial-to-mesenchymal transition (EMT), a process vital for development and wound healing but also associated with cancer metastasis. Its upregulation and mislocalization have been observed in several cancers, including breast and colon, correlating with poor prognosis and enhanced tumor formation and metastasis. Beyond oncology, reduced FAM3C levels are linked to the onset of sporadic Alzheimer’s disease. |