徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
DPF2 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611872 |
| 100ul | WGD-Z-2611872 |
详细参数
| 别名 | Zinc finger protein ubi-d4; Apoptosis response zinc finger protein; BRG1-associated factor 45D; BAF45D; D4; zinc and double PHD fingers family 2; Protein requiem |
| 基因名 | DPF2 |
| UniProt ID | Q92785 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 9R1-F3-K6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 44 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Double PHD fingers 2 (DPF2), also known as BAF45d, is a nuclear chromatin-associated protein that serves as an epigenetic reader within the SWI/SNF (BAF) remodeling complex. It contains a tandem double PHD finger motif that specifically recognizes and binds to modified histone H3 N-terminal tails, thereby facilitating the regulation of gene transcription, apoptosis, and NF-kappaB-dependent inflammatory responses. Clinically, DPF2 is implicated in hematologic malignancies, with recurrent gene rearrangements and altered expression observed in acute myeloid leukemia. Furthermore, germline variants in DPF2 have been associated with distinct neurodevelopmental and immunologic phenotypes, suggesting that it plays a dosage-sensitive role in both development and immune system function. Its ability to link chromatin modification to transcriptional output makes it a key regulator of cellular identity and homeostasis. |