徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
TRIM63 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611881 |
| 100ul | WGD-Z-2611881 |
详细参数
| 别名 | E3 ubiquitin-protein ligase TRIM63; Iris RING finger protein; Muscle-specific RING finger protein 1; MuRF-1; MuRF1; RING finger protein 28; RING-type E3 ubiquitin transferase TRIM63; Striated muscle RING zinc finger protein; Tripartite motif-containing protein 63 |
| 基因名 | TRIM63 |
| UniProt ID | Q969Q1 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3H4-U4-X8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 40 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Tripartite motif containing 63 (TRIM63), also known as MuRF1, is an E3 ubiquitin ligase localized to the Z-line and M-line lattices of myofibrils in striated muscle. It plays a central role in muscle protein catabolism by mediating the ubiquitination and subsequent proteasomal degradation of key structural proteins, including myosin heavy chain, myosin light chain, and muscle-type creatine kinase. TRIM63 expression is significantly upregulated during skeletal muscle atrophy induced by denervation, immobilization, or glucocorticoid treatment. Beyond its role in skeletal muscle, it regulates cardiac troponin I degradation and influences muscle hypertrophy through PKC-mediated signaling. Clinically, TRIM63 is associated with hypertrophic cardiomyopathy, where homozygous or compound heterozygous mutations lead to concentric left ventricular hypertrophy and dysfunction. It is also linked to the pathogenesis of Danon Disease. |