徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
IQCD Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611893 |
| 100ul | WGD-Z-2611893 |
详细参数
| 别名 | Dynein regulatory complex protein 10; IQ domain-containing protein D);IQ motif containing D |
| 基因名 | IQCD |
| UniProt ID | Q96DY2 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3G5-V9-L4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 52 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Dynein regulatory complex subunit 10 (IQCD) is a critical component of the nexin-dynein regulatory complex (N-DRC), which is essential for the motility of cilia and flagella. It functions by maintaining the structural alignment and integrity of the axonemal 9+2 microtubule arrangement, regulating the sliding and bending motions driven by dynein motors. Through its protein-binding activity, IQCD coordinates the functions of outer and inner dynein arms, preventing excessive doublet splaying and supporting the oscillatory bending required for effective ciliary movement. Although deficiencies in other N-DRC components are linked to primary ciliary dyskinesia, there are currently no established human diseases directly attributed to mutations in the IQCD protein itself. |