徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
PGLYRP4 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611912 |
| 100ul | WGD-Z-2611912 |
详细参数
| 别名 | Peptidoglycan recognition protein 4; Peptidoglycan recognition protein I-beta; PGLYRPIbeta; PGRP-I-beta; Peptidoglycan recognition protein intermediate beta |
| 基因名 | PGLYRP4 |
| UniProt ID | Q96LB8 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1W6-M6-Y7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 40 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Peptidoglycan recognition protein 4 (PGLYRP4) is a secreted pattern recognition receptor that plays a vital role in innate immunity by targeting Gram-positive bacteria. It contains two peptidoglycan-binding domains and functions as a glycosylated homodimer or a heterodimer with PGLYRP3. PGLYRP4 is constitutively expressed in barrier tissues, including the skin, mucous membranes, and intestinal tract, where it binds to murein peptidoglycans at bacterial cell-separation sites. Its bactericidal mechanism involves inducing lethal envelope stress through simultaneous oxidative, thiol, and metal stress responses, which effectively shut down bacterial transcription and translation without requiring membrane permeabilization or cell wall hydrolysis. This protein works synergistically with other antibacterial peptides to provide a robust defense against microbial pathogens at epithelial surfaces. |