徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
NAP1L3 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611936 |
| 100ul | WGD-Z-2611936 |
详细参数
| 别名 | Nucleosome assembly protein 1-like 3 |
| 基因名 | NAP1L3 |
| UniProt ID | Q99457 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6C8-N7-P8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 57 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Nucleosome assembly protein 1 like 3 (NAP1L3) is a nuclear histone chaperone belonging to the nucleosome assembly protein (NAP) family. It plays a critical role in chromatin remodeling and transcriptional regulation by binding core histones and facilitating nucleosome assembly during DNA replication and mitosis. NAP1L3 is particularly essential in hematopoietic stem cells, where it maintains the stem cell pool and regulates proliferation and differentiation. Mechanistically, it influences the expression of key regulatory genes, including MYC, E2F targets, and HOXA clusters. Depletion of NAP1L3 leads to G0 cell-cycle arrest and apoptosis, highlighting its importance in cell-cycle control and genomic stability. |