徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
DPCD Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611960 |
| 100ul | WGD-Z-2611960 |
详细参数
| 别名 | Protein DPCD |
| 基因名 | DPCD |
| UniProt ID | Q9BVM2 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 9Z4-H9-V1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 23 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Deleted in primary ciliary dyskinesia homolog (mouse) (DPCD/Dpcd) encodes a small, conserved cytoplasmic protein implicated in the generation and maintenance of motile ciliated cells, with expression upregulated during ciliated cell differentiation in mouse airways and brain ependyma. Functional studies indicate that DPCD interacts with the R2TP co-chaperone complex and Akt kinase to regulate initiation of ciliogenesis, suggesting a role in organizing protein complexes needed for axoneme assembly and ciliary function. Mouse Dpcd shows broad developmental expression and annotated molecular functions that include cytoskeletal protein binding and carbohydrate derivative binding, consistent with participation in cilium-related structural and signaling pathways. In a classic mouse model, deletion of Dpcd underlies primary ciliary dyskinesia with defects in dynein inner arms, leading to impaired ciliary motility. Correspondingly, disruption of DPCD is linked to human ciliopathy phenotypes and has been associated with primary ciliary dyskinesia and related congenital disorders affecting mucociliary clearance. |