徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
PRSS22 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611989 |
| 100ul | WGD-Z-2611989 |
详细参数
| 别名 | Brain-specific serine protease 4; BSSP-4; Serine protease 22; Serine protease 26; Tryptase epsilon |
| 基因名 | PRSS22 |
| UniProt ID | Q9GZN4 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 9R1-E3-Q2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 33 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Serine protease 22 (PRSS22), also known as brain-specific serine protease 4 or tryptase epsilon, is a secreted trypsin-like serine endopeptidase belonging to the S1 family. It is primarily expressed in the airway epithelium and other tissues such as the esophagus and pancreas, where it contributes to proteolysis and extracellular matrix remodeling. PRSS22 exhibits serine-type endopeptidase and peptidase activator activities, influencing signaling pathways including PI3K and p53. Clinically, PRSS22 is significantly dysregulated in various malignancies, particularly colorectal cancer, where its upregulation in primary tumors and lymph nodes serves as a prognostic biomarker for recurrence and reduced survival. Its involvement in tumorigenesis and immune microenvironment modulation makes it a potential therapeutic target. |