徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
ANKRA2 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612017 |
| 100ul | WGD-Z-2612017 |
详细参数
| 别名 | Ankyrin repeat family A protein 2; RFXANK-like protein 2 |
| 基因名 | ANKRA2 |
| UniProt ID | Q9H9E1 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9N3-Q3-O4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 34 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Ankyrin repeat family A member 2 (ANKRA2) is a scaffold protein characterized by multiple ankyrin repeats that facilitate diverse protein-protein interactions, including binding to histone deacetylases and low-density lipoprotein particle receptors. It localizes to the cytosol and plasma membrane, where it serves as a key component of the 3M complex alongside CCDC8, CUL7, and OBSL1. Within this complex, ANKRA2 mediates interactions with HDAC4 and HDAC5, playing a regulatory role in protein complex assembly and the function of LRP2/megalin. Clinically, mutations in ANKRA2 are associated with Immunodeficiency 31B, characterized by recurrent infections due to T-cell and antibody deficiencies, as well as Familial Hypercholesterolemia 4, which involves elevated LDL cholesterol levels and increased cardiovascular risk resulting from receptor dysregulation. |