徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
AS3MT Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612026 |
| 100ul | WGD-Z-2612026 |
详细参数
| 别名 | Arsenite methyltransferase; Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase |
| 基因名 | AS3MT |
| UniProt ID | Q9HBK9 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1E2-M6-T4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 41 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Arsenite methyltransferase (AS3MT) is a cytosolic enzyme that plays a central role in the detoxification and metabolism of inorganic arsenic. It catalyzes the transfer of methyl groups from S-adenosyl-L-methionine (AdoMet) to trivalent arsenicals, converting inorganic arsenite into monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). These methylated metabolites are less toxic and more readily excreted, thereby reducing arsenic retention in tissues. Beyond its primary metabolic function, AS3MT has been shown to facilitate NLRP3 inflammasome activation through m6A modification during arsenic exposure. Clinically, genetic variations in AS3MT influence individual susceptibility to arsenic toxicity, and the gene is associated with conditions such as centronuclear myopathy and specific lung carcinomas. |